ea0093oc54 | Oral communication 9: Calcium and Bone | EYES2023
Schoerding Ann-Kathrin
, Geist Daniela
, Hones G Sebastian
, Moller Lars Christian
, Williams Graham Richard
, Bassett John Howard Duncan
Background: Thyroid hormone (TH) action is mediated by TH receptors (TRs) α&β. Both regulate gene expression by binding TREs on the DNA (canonical signaling) or activate cellular signaling pathways (noncanonical signaling). Bone is a major TH target and noncanonical TR α & β effects on bone metabolism were suggested. We studied mouse model bones to distinguish between signaling types.Methods: Growth of WT mice and mice with ei...